The zebrafish (Danio rerio) is widely used as laboratory model organism. However, the hyper-stable conditions used to raise and breed lab lines are not expected to favour adaptive plasticity. Comparing domesticated fish with wild-derived fish presents a unique opportunity to study the evolution of plasticity, including intergenerational plasticity, and the underlying mechanisms of gene regulation. We combine intergenerational stress exposure experiments with whole genome sequencing data to obtain insight into the genetic evolution of epigenetic mechanisms following domestication, and into the effects of genetic variants on non-genetic inheritance.
Project team: James Ord, Dragan Stajic, Anastasiia Berezenko, Irene Adrian-Kalchhauser
Collaborator: Frederik Jutfelt, NTNU Norway
